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Product name: Vinpocetine
Specification: 98% Test method: HPLC
Appearance: White or slightly yellow, crystalline powder
Vinpocetine is a synthetic alkaloid derived from the periwinkle plant (specifically, synthesized from the molecule known as 'vincamine') that appears to have a track record of usage in European countries for the treatment of cognitive decline, stroke recovery, and epilepsy. Vinpocetine is also commonly used as a nootropic compound in the hopes that it may promote memory formation.
Vinpocetine is not fully absorbed, but what has absorbed peaks in the blood rapidly and easily enters the brain where it can exert its functions. The properties that appear to apply to oral vinpocetine supplementation include neuroprotection (against toxins and excess stimulation) and reducing neural inflammation, whereas the cognitive enhancement effect does not appear to be well supported by evidence at this point in time. While vinpocetine does appear to be effective in preventing toxins or stressors from causing amnesia, it is not yet demonstrated to inherently improve memory formation.
Vinpocetine also appears to have some efficacy against cognitive decline, but the amount of literature on this topic is much less than other drugs tested for this purpose (CDP-Choline or Alpha-GPC in particular). At least one study has noted an improvement in reaction time with a 40mg tablet of vinpocetine, which may be one of the only practically relevant improvements for healthy persons at this moment in time.
Is a Form Of
Cognitive Function and Brain Health
It goes well with nitrate (and possibly other nitric oxide inducers) and food intake (increases absorption rates).
How to Take
Vinpocetine is taken in the daily dosage range of 15-60mg, divided into three daily doses with meals. The standard low dose is 5mg at each of these three meals, with 20mg at each meal being seen as the higher end of efficacy. These doses are taken for the purposes of neuroprotection, enhancing cerebral blood flow, and reducing the rate of cognitive decline.
Doses in the higher end of that range (30-45mg acute dosages) may be useful for promoting cognition and memory formation in otherwise healthy persons, but there is not a lot of evidence looking at this claim.