Product name: Pyrroloquinoline Quinone Disodium Salt (PQQ)
Specification: 99% Test method: HPLC
Appearance: Reddish brown powder
Pyrroloquinoline quinone (henceforth PQQ) is a small quinone molecule which has the ability to be a REDOX agent, capable of reducing oxidants (an antioxidant effect) and then being recycled by glutathione back into an active form. It appears to be quite stable as it can undergo several thousand cycles before being used up, and it is novel since it associates with protein structures inside the cell (some antioxidants, mostly notably carotenoids like β-carotene and astaxanthin, are located at specific areas of a cell where they exert proportionally more antioxidant effects due to proximity; PQQ seems to do these near proteins like carotenoids do so at the cell membrane).
PQQ seems to modify oxidation in a cell after binding to some proteins, and this modulatory role it plays can alter the signaling processes that go on in a cell. Due to PQQ being a REDOX agent (capable of both reducing and oxidizing) it is not a pure antioxidant, but it is involved in a cyclical antioxidative cycle with an antioxidant enzyme known as glutathione
A large amount of the evidence for a direct antioxidant role or the neurological actions related to NMDA signaling of PQQ seems to use very high concentrations in cells, due to possible transportation issues to the brain and low concentrations of PQQ found in the blood following oral ingestion.
It holds a potential to modify signaling in humans, and although the oxidation in the blood (easiest thing to measure) in mostly unaffected it also retains the potential to act as an intracellular antioxidant. The enhancement of mitochondrial function may also occur, but beyond some alterations, in signaling and the mitochondrial biogenesis most other properties of PQQ are unlikely to extend to humans
Is a Form Of
Anti-aging and Longevity
Antioxidant and Anti-inflammatory
How to Take It
The optimal dosage of Pyrroloquinoline quinone (PQQ) to be taken daily is currently not known, but extrapolations from animal studies suggest that doses as low as 2mg are somewhat bioactive while most dietary supplements are sold in the 20-40mg range.