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The Role Of Fisetin For Anticancer Potential
- Feb 25, 2021 -

The findings discussed below stem from preliminary clinical research and animal studies. They should guide further investigation but shouldn’t be interpreted as supportive of the anticancer effects until more research is done. Fisetin isn’t approved for cancer prevention or treatment.

The Role of Fisetin for Anticancer Potential(1)

Inflammation is linked to colon cancer growth, as well as it’s spread and resistance to chemotherapy. In a clinical study of 37 colon cancer patients undergoing chemotherapy, fisetin (100 mg/day for seven weeks) reduced markers of inflammation (IL-8 and hs-CRP). However, the authors didn’t report the effects on tumor growth and progression.

In rats, fisetin reduced oxidative stress and the growth of liver cancer caused by fungal toxins.

In mice, it prevented the growth of lung cancer and boosted low antioxidant levels caused by a toxin in tobacco smoke. It reduced lung tumor growth by 67% in mice and by 92% when combined with a chemotherapy drug. It also prevented the growth of new blood vessels supplying nutrients to the cancer.

Another study found that fisetin reduced tumor growth by 66% in mice with melanoma.

Certain types of prostate cancers are fueled by androgens such as testosterone and dihydrotestosterone (DHT). Fisetin slowed the growth of prostate tumors in mice by blocking the receptors for testosterone and DHT on cancer cells.

Fisetin also protected against kidney damage from chemotherapy in rats by reducing inflammation and boosting antioxidant levels.

In cell studies, fisetin causes programmed cell death and prevents the growth and spread of a variety of cancer cell lines.

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