Two side effects and coping methods of NMN summarized by the side effect of NMN Powder use:
Possible principle: One possibility is that NAD+ promotes the synthesis of dopamine and causes excitatory effects. Another possibility is that after the level of NAD+ increases, the repair effect of sleep on neurons is accelerated, resulting in a decrease in the need for sleep. Studies have shown that NMN can enhance the mitochondrial function of mice with mutations in the biological clock.
Coping method: reduce the dose, or take NMN in the morning.
Possible principle: Histone deacetylase SIRT1, which relies on NAD+, participates in the regulation of the biological clock. This regulation mechanism is more complicated. Studies have shown that NMN can reduce the excitability of mice with mutations in the biological clock. Perhaps this may explain why some Friends who liked to stay up all night became sleepy earlier after taking NMN.
Coping method: Reduce the dose and take NMN in the morning. If it doesn't work, develop a good habit of going to bed and getting up early.
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