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Melatonin For Sleep: How Long Does It Work?
- Sep 07, 2021 -

It isn't a single correct answer for “How long does melatonin work?”, because melatonin affects everyone differently.


However, research shows that people's melatonin levels usually start to work between 20 minutes to 2 hours after taking a normal dose. And melatonin levels will reach a peak within an hour. In the same study, melatonin levels returned to normal after 4-8 hours. After melatonin is absorbed in the body, 30-50% can enter the blood, the effect of the drug in the plasma is about 35-50 minutes. Then begins to decline and is finally metabolized by the liver and excreted by the kidneys. Therefore, the concentration of melatonin in the body becomes higher about half an hour after taking it. According to melatonin's mechanism of action, it can effectively adjust sleep. This time it is easy to fall asleep.

So, in order to ensure the effectiveness of the drug accurately, it is recommended that you take melatonin about 1 hour before bedtime. In this way, your insomnia symptoms can be treated and the effect of drugs can be maximized.

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