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​JAFC Cover Article: 3,3-diindolylmethane Can Improve Intestinal Permeability
- Apr 20, 2020 -

Recently, researchers from the Korea Academy of Science and Technology published a cover article entitled "3,3′-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal Caenorhabditis elegans" in the international journal "Journal of Agricultural and Food Chemistry".


Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative enteritis, as a chronic inflammatory gastrointestinal disease, is increasing worldwide. Environmental and genetic factors such as smoking, stress, medications, and diet can all affect the occurrence and severity of inflammatory bowel disease. Unhealthy diets include fast-food diets, high-sugar, and low-fiber diets, red processed meat and small amounts of vegetables can cause intestinal microbial disturbances, intestinal permeability disorders, and chronic intestinal inflammation. Relative to traditional steroid-saving drugs and immunomodulatory drugs, supplementing healthy phytochemicals in the diet is considered a better choice.


Cruciferous vegetables such as broccoli, cabbage, and kale are rich in Indole-3-carbinol. When the gastrointestinal tract digests Indole-3-carbinol, it can produce our known metabolite-3,3-diindole Methane (DIM). Previous studies have found that DIM is an anti-inflammatory substance, which has the effect of inhibiting and treating various human colorectal cancer and experimental colitis in mice.

At current studies, DIM is found it can repair the intestinal permeability of differentiated Caco-2 cells (a human cloned colon adenocarcinoma cell) by increasing the expression of tight junction proteins.

Therefore, by improving intestinal permeability, DIM can provide a potential functional food option for the treatment of intestinal leakage syndrome.

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