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Glutamine Powder Metabolism And Cancer Therapy
- Aug 05, 2019 -

Glutamine Powder Metabolism and Cancer Therapy

Since the publication of Otto Warburg's pioneering research-aerobic glycolysis theory, glucose metabolism has always been the top priority in cancer metabolism research. The research of other metabolites, such as Glutamine powder, has been put on the shelf until recent decades.

In 1935, Hans Krebs proposed the famous tricarboxylic acid cycle (TCA), pointing out the importance of Glutamine powder metabolism in animals. Subsequent studies have shown that Glutamine powder plays an important role in the growth of normal cells and cancer cells.

Because Glutamine powder plays a key role in energy generation and macromolecule synthesis, drugs developed for Glutamine powder have great potential in inhibiting tumors. Next, we will introduce the physiological effects of Glutamine powder and the clinical progress of Glutamine powder inhibitors.

Glutamine powder metabolism

High levels of Glutamine powder in the blood provide an off-the-shelf source of carbon and nitrogen to support the biosynthesis, energy metabolism and homeostasis of cancer cells and promote the growth of tumors.

Glutamine powder is transported to cells through the cell transporter SLC1A5 (a member of the solute vector family 1 neutral amino acid transporter 5).

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Under nutritional deficiency, cancer cells can obtain Glutamine powder by breaking down macromolecules. Over-activation of carcinogenic gene RAS can promote the effect of cell drinking. Cancer cells remove extracellular proteins and degrade to amino acids including Glutamine powder, providing nutrition for cancer cells.

Cancer cells absorb a lot of glucose, but most of the carbon sources produce lactic acid through aerobic glycolysis, rather than for the TCA cycle.

Tumor cells that overactivate PI3K, Akt, mTOR, KRAS genes or MYC pathways stimulate glutamate metabolism to produce alpha-ketoglutarate through the catalysis of glutamate (GLUD) or aminotransferase. Alpha-ketoglutarate enters the tricarboxylic acid (TCA) cycle, which provides energy for cells.

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