Home > What We Know > Content
Diindolylmethane Powder Inhibits Obesity Induced By High-fat Diet
- Oct 12, 2020 -

Indole-3-carbinol is a derivative that is abundant in cruciferous vegetables (such as cabbage) and is widely known for its various health benefits (such as chemoprevention and anti-obesity effects). Under the acidic conditions of the stomach, I3C is easily metabolized into the more stable Diindolylmethane powder. However, the anti-obesity effect of DIM has not been clearly studied. We tried to study the effect of DIM on diet-induced obesity and clarify its underlying mechanism.


High-fat diet (HFD)-fed obese mice and MDI-induced 3T3-L1 adipogenesis model was used to study the effects of DIM. We observed that the administration of DIM (50 mg/kg BW) significantly inhibited HFD-induced obesity, accompanied by adipose tissue reduction. In addition, we observed that DIM treatment (40 and 60 μM) instead of I3C treatment significantly inhibited MDI-induced adipogenesis by reducing the levels of several adipogenic proteins (such as PPAR-γ and C/EBPa). DIM, but not I3C, inhibits the G1 cell cycle progression that occurs in the early stages of adipogenesis and induces the post-translational degradation of cyclin D1 by inhibiting the activity of ubiquitin-specific peptidase 2 (USP2).

Diindolylmethane powder


Our research results show that cruciferous vegetables that can produce Diindolylmethane powder metabolites have the potential to prevent or treat chronic obesity.

For any query or further information, welcome contact info@unipharmpro.com. Unipharmpro would always provide you an all-in-one solution.

Related Products