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Diindolylmethane Powder Inhibits Obesity Induced By High-fat Diet
- Oct 12, 2020 -

Indole-3-carbinol is a derivative that is abundant in cruciferous vegetables (such as cabbage) and is widely known for its various health benefits (such as chemoprevention and anti-obesity effects). Under the acidic conditions of the stomach, I3C is easily metabolized into the more stable Diindolylmethane powder. However, the anti-obesity effect of DIM has not been clearly studied. We tried to study the effect of DIM on diet-induced obesity and clarify its underlying mechanism.


METHODS AND RESULTS

High-fat diet (HFD)-fed obese mice and MDI-induced 3T3-L1 adipogenesis model was used to study the effects of DIM. We observed that the administration of DIM (50 mg/kg BW) significantly inhibited HFD-induced obesity, accompanied by adipose tissue reduction. In addition, we observed that DIM treatment (40 and 60 μM) instead of I3C treatment significantly inhibited MDI-induced adipogenesis by reducing the levels of several adipogenic proteins (such as PPAR-γ and C/EBPa). DIM, but not I3C, inhibits the G1 cell cycle progression that occurs in the early stages of adipogenesis and induces the post-translational degradation of cyclin D1 by inhibiting the activity of ubiquitin-specific peptidase 2 (USP2).

Diindolylmethane powder

CONCLUSION

Our research results show that cruciferous vegetables that can produce Diindolylmethane powder metabolites have the potential to prevent or treat chronic obesity.

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