Exposure to ionizing radiation causes damage to the genomic integrity and stability of the cell. Though a large number of molecules have been studied for their radioprotective capability, no single agent is available today that meets all the requirements of a good radioprotector. 

In this study, we have investigated a combination of Resveratrol (RSV) and diindolylmethane powder (DIM) for its efficacy for radioprotection. We are assuming that this combination that possesses less toxicity than synthetic compounds, free radical scavenging potential, and the capacity to interfere with several of the signaling cascades that trigger damage to cells by ionizing radiation may possess the good radioprotective capability.

Based on the above assumption, we found mice were pre-treated with a combination of RSV and diindolylmethane powder and the 30-day mortality assay, endogenous antioxidant levels in the intestinal mucosa, metaphase chromosomal aberrations, and micronuclei formation were assessed after exposure to ionizing radiation.

It is found that pre-treatment with the combination of RSV and diindolylmethane powder protects effectively from the ionizing radiation-induced damage at the molecular, cellular, and tissue levels by counteracting both the direct and indirect effects.

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