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Application of L-theanine in Medicine
- Jun 06, 2019 -

1. Antineoplastic effect of L-theanine

L-theanine can not only increase the anticancer activity of anticancer drugs against primary cancer, but also inhibit the metastasis of cancer cells. L-theanineis a derivative of glutamine, and the glutamine metabolism of cancer cells is much more active than that of normal cells. Therefore, theanine, as a competitor of glutamine, inhibits the growth of cancer cells by interfering with glutamine metabolism.

Studies on mice have shown that oral green tea can not only reduce the formation of tumors, but also significantly reduce their size. Some researchers believe that L-theanine can increase the anti-tumor activity of the anti-cancer drugs Adriamycin and Doxorubicin (DOXORUBICIN) in mice, and combine with L-theanine to resist the metastasis of cancer cells. At the same time, the anti-cancer drug PIRARUBICIN was prevented from flowing out of M5076 tumor cells, and the concentration of PIRARUBICIN in tumor cells increased 113 times, which increased the therapeutic effect of PIRARUBICIN by 117 times.


2. Hypotensive effect

The regulation of blood pressure is mainly achieved through the increase or decrease of catecholamine and 5-hydroxytryptamine in central and peripheral nervous systems. After administration of rat theanine, the content of serotonin was reduced, the synthesis of serotonin in the brain was reduced, and the decomposition of serotonin in the brain was increased.

When different doses of L-theanine were injected into spontaneously hypertensive rats (SHR), the blood pressure decreased in a dose-dependent manner, and a significant decrease in blood pressure was observed in the high-dose group. But even the highest dose of L-theanine(2000MG/KG) did not change the blood pressure of WISTAR rats. Glutamate, which is similar to L-theanine in structure, has no effect on lowering blood pressure.

3. The Important Role of L-theanine in the Nervous System

We all know that brain neurotransmitters are closely related to improving memory and learning ability. Terashima et al. found that L-theanine can significantly increase the brain neurotransmitter dopamine and improve memory. In the Operanttests and Avoidancetests experiments, the learning and memory abilities of the rats with L-theaninein water were improved, which showed that the learning and memory time was significantly shorter than that of the rats without theanine.

L-theanine has been found to influence the synthesis and decomposition of serotonin in the brain by using serotonin (5-hydroxytryptamine) metabolic inhibitors. After taking theanine, tryptophan content in the brain increased significantly or tended to increase, but serotonin content decreased. L-theanine may reduce serotonin synthesis and increase its decomposition, or inhibit serotonin release.

By giving different doses of L-theanine to mice 30 days later, it was found that L-theaninecould significantly prolong the swimming time of mice under load, reduce the consumption of hepatic glycogen, and reduce the level of serum urea nitrogen during exercise. L-theanine could significantly inhibit the increase of blood lactic acid in mice after exercise, and promote the elimination of blood lactic acid after exercise, which indicated that L-theaninehad the function of reducing blood lactic acid after exercise. Anti-fatigue effect.

4. Sedation 

Caffeine is a well-known stimulant, but people actually feel relaxed, calm and relaxed while drinking tea. This has been shown to be primarily theanine.


5. Improve menstrual syndrome 

Most women have menstrual syndrome. Menstrual syndrome (PMS) is a mental and physical discomfort experienced by women between the ages of 25 and 45 three to 10 days prior to menstruation. In the spirit of the main performance is easy to be agitated, angry, depressed, restless, unable to concentrate, etc., in the body of the main performance is easy to fatigue, not easy to sleep, headache, chest pain, abdominal pain, lumbar acid, cold hands and feet, etc. Theanine's sedative effects suggest an improvement in menstrual syndrome, and clinical trials in women have shown its effect.

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