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Anti-estrogen Effect Of Indole 3 Carbinol Powder And Prevention Of Breast Cancer.
- May 14, 2020 -

    Indole 3 carbinol powder is one of the main components of the anti-cancer effect of cruciferous vegetables. The compound and several polymetabolites formed in the stomach can produce anti-estrogen biological effects in multiple ways, and estrogen is An important risk factor for breast cancer. so the anti-estrogen effect of indole 3 carbinol powder is an important mechanism for preventing breast cancer.

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So far, many studies have proved that Indole 3 carbinol powder can prevent breast cancer. 

The role of cruciferous vegetables in reducing the risk of breast cancer is mainly related to the ability of these vegetables to provide phytochemicals I3C. 

Feeding mice with different concentrations of I3C feed (0, 500, and 2000 ppm) for up to 8 months of research found that I3C-containing feed can reduce breast tumorigenesis and tumorigenesis diversity in C3H / OH female mice The incubation period of tumor in mice in the dose group was prolonged. 

Studies have also confirmed that I3C prevents breast cancer animal models caused by direct carcinogens (such as MUN) or indirect carcinogens (such as DMBA), which significantly reduces the diversity of breast tumors, and has a good effect in the initiation and promotion stages of cancer. Preventive effect. However, some studies believe that I3C can only play a preventive effect in the initiation stage of breast cancer, and can only prolong the incubation period after the initiation of tumors, and cannot prevent the occurrence of breast tumors and the diversity of tumors. I3C has a special anti-proliferative effect on breast cancer cells. 

In vitro studies have found that Indole 3 carbinol powder can inhibit the growth of estrogen-sensitive breast cancer cell line MCF-7, but only has a weak effect on insensitive cell lines. Human breast cancer cells were implanted into nude mice, and it was found that DIM inhibited the growth of implanted human breast cancer cells by 64%.


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