Here are 10 reasons why we switch to BHB:
1: ENHANCES GENE EXPRESSION
A lot of the benefits of BHB come from its ability to optimize the expression of your genes, aka the way your cells interpret DNA instructions. That’s why we’re starting with it.
Quick DNA function refresh:
DNA is the biological code that specifies how organisms grow, function, and reproduce, which rarely changes. DNA expression is simply how well this code is passed down to your cells, which can vary depending on several factors.
If DNA expression is impaired, your cells can’t create the proteins they need to survive.
DNA expression involves two steps:
Transcription: The DNA instructions for making a specific protein are copied into a messenger molecule called mRNA .
Translation: The mRNA is read and used to assemble the correct amino acids that form the protein.
Takeaway: BHB improves gene expression by unlocking important proteins that increase longevity and antioxidant protection.
2: SUPERCHARGES COGNITIVE FUNCTION
Ketones are able to cross the blood-brain barrier easily and provide your brain with over 70% of its energetic needs.
In fact, neurons consume a lot of BHB, at a rate of 0.032 mmol/kg/min.
This quick absorption improves brain function in many ways, including:
Preservation of neurons and synapses — which improves memory, focus, attention, and learning.
Fewer free radicals
Lower risk of dementia
Reduced risk of depression and mood disorders.
Improved cognition in people with dementia, including those with Alzheimer’s and Parkinson’s disease.
BHB also protects the central nervous system by preserving an important type of cell present in the brain and spinal cord called ramified microglia, which acts as a sensor scanning for potential threats and protects neurons.
Takeaway: Your brain can absorb ketones quickly, and ketones protect neurons, synapses, lower neuroinflammation, and prevent neurodegeneration.
3: KILLS INFLAMMATION
BHB blocks a platform responsible for inflammation called NLRP3 inflammasome.
NLRP3 unleashes inflammatory molecules that trigger neuroinflammation, cancer, insulin resistance, bone diseases, Alzheimer’s disease, skin diseases, metabolic syndrome, type 2 diabetes, and gout.
This anti-inflammatory power makes BHB useful for preventing diseases triggered or aggravated by inflammation.
For example, it may help treat inflammatory skin diseases like acne, psoriasis, varicose ulcers, allergic reactions, and skin photosensitivity.
Takeaway: BHB blocks the activity of the complex NLRP3 inflammasome, which is responsible for major inflammation in the body.
4: FIGHTS OXIDATIVE STRESS
Evidence finds BHB can prevent and reverse oxidative damage in the brain (neurons, hippocampus, neocortex) and blood:
One study found BHB prevented neuronal death.
Another study done on athletes found ketone bodies reduced the oxidative stress caused by exercise.
Takeaway: The antioxidant effects of manufacturing BHB protect your cells against oxidative damage, especially in the brain.
5. INCREASES LIFESPAN
BHB can help you live a longer, healthier life thanks to:
Its positive effects on gene expression
Its anti-inflammation powers (as explained before).
Basically, BHB unlocks helpful genes that work together to fight oxidative stress and improve metabolism, increasing longevity.
Takeaway: BHB can increase lifespan by activating anti-aging genes and slashing inflammation.
6. HELPS FIGHT AND PREVENT CANCER
BHB can slow down the growth of tumors because cancer cells can’t use ketones well enough to grow and spread.
Here’s what different studies have found:
When ketones replaced glucose as fuel, brain tumors shrank.
Ketones stopped the spread of metastatic cancer cells both in vivo and in vitro.
Ketone bodies killed pancreatic cancer cells and diminished cachexia.
Ketones also slowed down the growth neuroblastomas, cancer cells that form in nerve tissue.
Takeaway: Running on BHB impairs the growth of tumors.
7. BOOSTS INSULIN SENSITIVITY
Ketones improve insulin sensitivity by reducing insulin levels as well as blood glucose and mimicking the effects of insulin.
This can reverse insulin resistance — what happens when your body is forced to make extra insulin to deal with blood sugar.
When you’re sensitive to insulin, you’re at a lower risk of metabolic diseases such as type 2 diabetes, non-alcoholic fatty liver disease, and obesity.
Takeaway: BHB can improve insulin sensitivity and reverse insulin resistance by keeping glucose and insulin levels low.
8. OPTIMIZES HEART FUNCTION
In the normal adult heart, fatty acids provide up to 70% of ATP, while glucose, lactate, amino acids, and ketones supply the rest.
Studies found the mechanical efficiency of the heart increased by 30% and blood flow increased by 75% when running on ketones.
Takeaway: BHB is a better fuel for the heart. It protects against oxidative damage, enhances mechanical efficiency, and improves blood flow.
9: BOOSTS FAT LOSS AND WORKOUT PERFORMANCE
Your skeletal muscle also benefits from BHB, especially when exercising.
Exercise increases the absorption of ketones dramatically, and in turn ketones improve performance and recovery. It’s a cycle of goodness.
Takeaway: Exercises accelerates the absorption of BHB, and BHB boosts fat burning, recovery, and energy.
10: PREVENTS BONE DETERIORATION
BHB has impressive bone preserving abilities.
Research finds it can prevent bone degradation by stopping the production of cells called osteoclasts in subjects with osteoporosis.
One study found BHB:
Prevented bone density decline
Increased resistance to bone deformation
Boosted the strength of the femur
Improved the volume of the internal tissue of the bone (called cancellous or spongy bone)
Takeaway: BHB prevents the growth of cells that break down bone tissue and increases bone strength and resistance.
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